Factors which may progress Knee Osteoarthritis faster:
Prior knee surgery
Other diseases (Inflammatory related)
Coronary artery disease
Joint Mechanical problems (instability and ligamentous laxity)
Knock knees and bowlegs
Leg length differences
Abnormalities of adjacent joints hip, the other knee, or foot
These factors should be addressed if possible.
The effect of weight is significant. For each 10 pounds gained there is a 30-50 pound load increase on the knee. Women traditionally have smaller knee joints thus the available surface area to absorb these additional weigh related forces is reduced, there by accentuating the weight gain effects on the knee in women.
Inflammatory effects have not been shown to be altered long term with arthritis medications (NSAID’s) or cortisone injections.
Surgery and continued trauma accelerates the knee arthritis.
Inflammation may be modified by stem cells. The knee undergoes cartilage degeneration in osteoarthritis. This is a progressive disease state. Some progress at faster rates than others.
Stem cells may exert a positive anti-inflammatory effect on the knee cartilage resulting,in slower rates of degeneration, cessation of degeneration for a period of time (stopping Father Time) or may repair and regrow cartilage which reverses the degenerative effect of arthritis. Again this sets time back (like turning the clock back), however time will eventually begin ticking again but turning it back may add years of forestalling knee joint replacement, if stem cells are done early enough in the treatment of knee arthritis combined with modifying other risk factors like obesity and trauma, substantial changes may occur as a strategy to avoid knee replacement surgery.