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Knee Stem Cell Articles

Knee and Hip Arthritis

Knee and Hip Arthritis

Knee and Hip Arthritis

Degenerative osteoarthritis is not always confined to one joint. Many patients are afflicted with arthritis symptoms in the hands and legs. Athletes may have involvement of shoulders, hips and knees, or any combination from many prior injuries.

Not to mention the spine is all too frequently involved. Back pain is only second to the common cold in frequency of medical visits.

Arthritis of the knee and hip can be especially troublesome due to the cumulative effects of debility and pain in more than one location of the lower extremity. This compounds difficulty with walking, sports, recreational activities and impairs functional ability.

Surgery may have been performed on one or more of these joints, and all too frequently recommendations for total hip or knee replacement surgery has been rendered. Possibly surgery recommendations are given for each joint. At times a hip or knee has already been replaced, and now the other side is symptomatic. Sometimes the joint replacement surgery was not completely successful, or resulted in complications.

Stem Cell Therapy may be an option in these situations. Options include treating either the knee or hip or both. This is dependent on several factors and should be discussed with an expert in Regenerative Medicine. The use of Stem cells in multiple joints or being done serially or to the most problematic joint is best left to an individualized decision between the physician and patient. Not every patient should be treated alike or in the same fashion. Individual differences in patients may impact decision making by the experienced Regenerative Medicine specialist.

Dr. Dennis Lox is an expert in Sports and Regenerative Medicine. Contact Dr. Lox for an evaluation.

Knee ACL Tears and Stem Cells

Knee ACL Tears and Stem Cells

Knee ACL Tears and Stem Cells

The anterior cruciate ligament (ACL) is one of the most dreaded injuries. ACL surgery and recovery are often difficult.

The anterior cruciate ligament (ACL) functions to stabilize the knee and prevents the forward translation or movement of the knee joint when stopping or turning. By contrast the posterior cruciate ligament (PCL) does the reverse. This occurs by the cross formed by the two ligaments and their different attachments in the center of the knee joint.

The ACL is often injured with other knee tissues. The terrible triad is a tear of the ACL, medial meniscus, and MCL (medial collateral ligament).

This is common in sports such as basketball, football, skiing and soccer.

ACL tears do not have to be complete. Partial tears occur and these do not have to always be surgically corrected.

Partial tears may be amenable to therapy and Stem Cell Therapy.

Stem cell treatments in this case is to aid in the healing process, and to possible repair the partial tear. Complete ACL tears that have left the two ends of the ACL separated like a cut rope, cannot be fixed with stem cells unless the ends were together.

Special ACL braces can help prevent translational forces across the knee joint during recovery from stem cell treatment or as part of rehabilitation.

The use of Stem Cell Therapy in ACL partial tears associated with meniscal tears or other damaged tissues such as the MCL, may be a viable treatment option as well.

Stem cells actually home to sites of injury. This allows more than one site to be treated when the stem cells are placed inside the knee joint. This is advantage to patients recovering from the injury, especially athletes. Treatment should be individually tailored for each patient.

Knee Avascular Necrosis (AVN) treated with Stem Cells

Knee Avascular Necrosis (AVN) treated with Stem Cells

Knee Avascular Necrosis (AVN) treated with Stem Cells

Knee avascular necrosis (AVN) is a difficult disorder, and the use of stem cells for the treatment of AVN now is now being more readily applied. The concept of using stem cells to treat avascular necrosis is not new. Less specific and concentrated approaches of using stem cells for AVN have been used for many years with the use of core decompression.

Knee AVN is associated with debility and pain. Long term outcomes for AVN with joint collapse is poor, and usually leads to knee joint replacement. Alternatives to knee joint replacement are desired, as other options such as living with the pain, and loss of function and mobility are not very appealing.

Knee AVN is caused by the disruption of blood flow (ischemia) to a region of bone resulting in necrosis or bone cell death. The amount of necrotic area can influence outcome, as well as if contact with the knee joint surface or collapse has occurred.

Knee joint collapse is associated with the development of rapid secondary degenerative arthritis.

Knee AVN treatment with concentrated stem cells from the patients own body, is actually a collection of many types of stem cells, progenitor cells, vascular cells and other cell types which may all collectively be beneficial. Improving blood flow can be initiated by signals from various cell types and is very complex.

Regeneration of bone cells can involve the differentiation of stem cells into new bone cells or the recruitment of progenitor cells (precursor cells).

Stabilization of secondary degenerative arthritis or halting the development, is important for knee joint stability and prevention of joint collapse.

The complexity of knee avascular necrosis due to the many possible risk factors and the variations in different individual patients, necessitates an individualized treatment plan for each patient. There is no automated formula for treating knee AVN. The most optimal plan includes assessing each patient individually.

Knee Debility and Disability

Knee Debility and Disability

Knee Debility and Disability

Chronic knee pain is a frequent finding in those traumatically injured in sports or work. At as we age, the knee is the most common joint afflicted with arthritis. Knee osteoarthritis is the 6th leading cause of disability.

Trauma accelerates arthritis, and surgery is often performed for knee trauma. Knee surgery further accelerates knee joint arthritis. This leads to an ever increasing problem with time. Especially those that continue to have knee pain despite prior knee surgery.

This leads to further debility. Debility is the lack of functional level due to an injury or illness. A frequent secondary effect of debility is weight gain which may bring more medical problems further perpetuating the debility. Diabetes, heart disease, hypertension are all correlated with arthritis and obesity.

Disability is a more legal term rather than a medical description. It can take the meaning of lack of ability to continue working or maintain gainful employment as the result of debility. This can all result from an original knee injury, and become compounded by knee surgery, the development of arthritis, and weight gain related disease states.

The condition of disability can be met by the social security system in these types of situations. Unfortunate consequences to perhaps an unwanted and unwelcome knee injury.

Knee Stem Cells To Help Prolong Sports Careers

Stem Cell Therapy for knees is gaining popularity. Athletes with sports injuries have been utilizing Knee Stem Cell Therapy. The role of stem cell treatments in sports medicine has both scientific and regenerative applications.
Trauma accelerates the degenerative arthritis cascade. This is a continuos domino like effect. The normal repair processes of joint cartilage are disrupted and an imbalance exists in which breakdown exceeds repair. This results in a net loss of knee joint cartilage.

Knee surgery is generally done in sports medicine for athletes who sustain sports injuries to their knees. Surgery is a form of trauma. Knee surgery done for knee trauma results in more cumulative progression towards eventual knee osteoarthritis or arthritis.

It is not unusual for athletes who have knee surgery to later have more knee problems or early arthritis. This has occurred during many elite professional athletes career, often shortening their longevity in sports. Professional football running backs do not play often into their mid 30’s. Quarterbacks can play till 40, if their shoulders and knees are good. However many famous Quarterbacks such as Joe Namath, had his career shortened due to knee arthritis and prior knee surgeries.

Now professional athletes are being treated with stem cells after their surgery. Some display rapid recovery. Whether they will still develop knee arthritis or will this arthritis be lessened as a result of their being treated with knee stem cells will remain to be seen. One possibility would be that these patients may have less knee arthritic effects, compared to if they did not receive the stem cells after surgery. However if they continue to play more years, perhaps the extended sports career will expose them to more knee trauma than they would have had if they retired.

An interesting academic question would be what would Joe Namath’s knee looked like towards the end of his career, if he had been treated with knee stem cells post surgery, and would it have lengthened his career? Of course these are just speculative interesting questions that no answer exists for.

What about professional athletes who have knee surgery fail to improve and are eventually released by their team?

Some have improved in this situation after treatment with stem cell treatments.

Dr. Dennis Lox has treated such professional athletes with persistent knee problems. These athletes failed to improve after knee surgery, and then they subsequently improved after knee stem cell treatments with Dr. Lox. Later the athletes we’re resigned to another professional sports franchise. Different situations do exist. Not all patients are alike and should not be treated as though they are all alike.

Optimal treatment requires optimal assessment and experience.

Knee Osteonecrosis (AVN)

Knee Osteonecrosis

Knee Osteonecrosis

Knee osteonecrosis is another name for avascular necrosis (AVN)
There are several names for this medical condition:

Knee osteonecrosis
Knee avascular necrosis (AVN)
Knee ischemic necrosis
Knee aseptic necrosis
Knee bone infarction
Knee bone infraction

Osteonecrosis and avascular necrosis (AVN) are the most common terms. Differences in regional preferences or authors may have a predilection for one term.

Osteonecrosis Definition
A loss of blood supply to a region of bone results in bone cell death. Bone refers to osteo, and necrosis refers to bone cell death. Avascular refers to the loss of blood supply.

Osteonecrosis of the knee may be present in any bone surrounding the knee. Most commonly the femur or tibia.

The extend of osteonecrosis can influence the course of the condition. Osteonecrosis of larger regions of bone in close proximity to the knee joint may collapse. If the necrotic bone collapses, a rapid secondary joint arthritis can follow often with recommendations for total knee joint replacement.

Alternatives to knee joint replacement are often sought. Younger patients and athletes are more impacted by the prospect of knee joint replacement, though all patients typically would like an alternative if reasonable to knee joint replacement. Younger patients have to deal with the lifespan of the knee implant, while athletes may not return to their chosen career after knee joint replacement.

Stem Cell Therapy has been included as an alternative to knee joint replacement for patients with knee osteonecrosis or avascular necrosis (AVN). This decision should be made with an experienced Regenerative Medicine physician who understands osteonecrosis and has treated this condition with Stem Cell Therapy.

Dr. Dennis Lox is an expert in Sports and Regenerative Medicine. Dr. Lox has treated many patients with a variety of types of osteonecrosis or AVN, including the knee. Dr. Lox has also treated athletes with AVN successfully with Stem Cell Therapy, including soccer players, tennis players and even ballerinas with knee osteonecrosis.

Knee AVN Washington DC Stem Cells with Dr. Lox

Knee AVN Washington DC Stem Cells with Dr. Lox

Knee AVN Washington DC Stem Cells with Dr. Lox

Dr. Dennis Lox a Sports and Regenerative Medicine expert in the Washington, D.C. metro region consults on a variety of knee conditions to treat with Stem Cell Therapy.

The Washington DC area is home to many professional sports franchises and has an active athletic community. Knee avascular necrosis (AVN) is not as common in the leg as hip AVN, however like hip AVN, it is most frequently caused by trauma. Avascular necrosis (AVN) occurs when the blood supply to a region of bone becomes impaired leading to a region of bone cell death or necrosis. This area of AVN necrosis may ultimately collapse, resulting in a rapid knee joint secondary degenerative arthritis.

As is the case with knee osteoarthritis, it tends to progress with time, however knee AVN may have a much more rapid acceleration of the arthritis curve. This makes timely treatment essential. Traumatic induced AVN may not initially be considered serious, and therefore conservative measures such as rest are thought to bring about improvement. The lack of improvement may be the first signal of something really wrong such as AVN. Other causes or risk factors of knee AVN are spontaneous onset, steroid induced, excessive alcohol consumption, chemotherapy, radiation, coagulopathies and autoimmune disorders.

Stem cell treatments have been considered a possible viable option for some patients with AVN. Stem Cell Therapy may work on several pathways including immunomodulation, cell signaling, repair or regenerative responses.

Many patients desire alternatives to knee joint replacement. Younger patients and athletes diagnosed with AVN are especially concerned with knee joint replacement.

Athletes may have career ending injuries when diagnosed with AVN. Younger patients must weigh the lifespan of a knee joint implant with their young age.

For many patients with knee arthritis or knee AVN alternative strategies such as Stem Cell Therapy may be a viable option for some patients.

Patients with chronic knee pain, arthritis or AVN may consult Dr. Lox in the Washington, D.C. Metro area.

Patient From Dubai Consults Dr. Lox For Knee Stem Cells

Patient From Dubai Consults Dr. Lox For Knee Stem Cells

Patient From Dubai Consults Dr. Lox For Knee Stem Cells

A patient from Dubai, with knee arthritis consulted Dr. Dennis Lox for knee stem cell injections. His knee arthritis had been present for several years with gradual worsening of symptoms. Pain, increased with prolonged walking was his main difficulties. He was told he needed a total knee replacement surgery, and desired to be treated with knee stem cell injections as an alternative strategy.

Dr. Lox treats many patients from around the world. Dr. Lox is an expert in Sports and Regenerative Medicine, specializing in the treatment stem cell injections.

Many patients visit his office in Florida to take advantage of a beach holiday, as well as a knee tuneup with stem cells.

Knee Joint Swelling and Stem Cells

Knee joint swelling may occur for a variety of reasons. Possible causes are injury to the knee joint, degenerative arthritis, infectious and inflammatory processes.

Knee injury resulting in knee swelling. may be a known traumatic injury, a prior injury or an underlying degenerative meniscal tear that was previous silent or symptomatic.

Degenerative or osteoarthritis may cause knee swelling often referred to as an effusion. Some patients may have so much swelling, the knee joint must be drained as it interferes with mobility and is quite painful.

Infections can present as knee swelling. The knee joint may be hot and swollen. Though heat and swelling is not limited to infections. Laboratory analysis, fever, or joint fluid analysis may determine this.

Arthritis processes are not limited to osteoarthritis. The autoimmune disorders rheumatoid arthritis, lupus, and psoriatic arthritis may present as knee swelling.

Joint crystals as in in gout or pseudo gout may also be present in knees resulting in swelling.

Knee Stem Cell Therapy for swelling related to injury, prior trauma, including surgery may be considered. Stem cell treatments for knee arthritis are more common, including as an alternative to knee joint replacement.

Knee Stem Cells and Obesity

Knee Stem Cells and Obesity

Knee Stem Cells and Obesity

Knee problems are a common condition. Knee stem cell treatments are becoming more common. Obesity in the United States and other developed countries continues to escalate.

Most individuals who have knee pain are aware that being overweight is not good for their knees. Often despite this knowledge and even told they have knee arthritis, they still do not lose the weight.

Sometimes it is being told they need a knee replacement or worse two knee replacement surgeries, that is what finally gets their attention. In some cases their weight is so much that they fall into the obesity category and are told by the orthopedic surgeon that knee replacement cannot be done until they lose weight. This leaves these patients with knee pain and often debility.

A frequent complaint is that they hurt so much that they can’t exercise to lose the weight and their immobility may even result in more weight gain.

Dr. Dennis Lox a Sports and Regenerative Medicine expert is often consulted on these difficult cases. The proverbial catch 22 situation, sometimes has a solution.

At times stem cells can be placed into the knee of the overweight patient to reduce pain, improve mobility and function to jump start the weight loss effort. This is often more complicated than it seems. This is why an expert in Regenerative Medicine such as Dr. Lox is invaluable to the treatment as modifications to the treatment must be done to address factors which will hinder the effectiveness of knee stem cell treatment in overweight and obese patients.

Not all patients are alike, and not all overweight patients are alike. Individual factors which are important to treatment success is essential to achieve the best outcome.